NOCICEPTION – PHYSICAL REACTION TO A PAINFUL STIMULUS


In contrast to pain, which is defined as a subjective sensorial or emotional event, nociception means the reception, transmission and central nervous processing of noxious (tissue-damaging or potentially tissue-damaging) stimuli. The painful stimulation referred to as nociceptive stimulation activates specific pain receptors called "nociceptors". Nociceptors are free nerve endings that are excited by damaging stimuli arising from various causes. Most nociceptors are polymodal, i.e. they react to several different types of stimuli, e.g. thermal, mechanical and chemical stimuli. They are present in large numbers in the skin, but are also found in the muscles, periosteum, the capsules of internal organs and the walls of vessels and hollow organs. There are no nociceptors in the brain.

 

Nociceptors