Concomitant or Co-Analgesics were originally developed to treat medical conditions other than pain but have been found to have pain-relieving properties.

They are used 

to enhance the analgesic efficacy of analgesics

to treat concurrent symptoms that intensify pain

to provide independent analgesia for specific types of pain like neuropathic pain



The main classes of co-analgesics are 

Anticonvulsants (e.g. gabapentin, pregabalin)

Antidepressants (e.g. amitriptyline, duloxetine)

- TCA (e.g. amitriptyline)

- SNRI (e.g. duloxetine)

Anxiolytics (e.g. diazepam)

Neuroleptics (e.g. haloperidol)

Corticosteroids (e.g. prednisolone)


Pain Treatment

Learn more about:

  Non-pharmacological treatment



  Topical Analgesics



How do Co-Analgesics relieve Pain

Learn about the mechanisms of action of Anticonvulsants and Antidepressants


  Antidepressants - TCA

  Antidepressants - SNRI


New Concepts in Pain

Learn more about new concepts meeting the complexity of pain.

New concepts


eCME Courses


CHANGE PAIN provides you with eCME courses – accredited by Union Européenne des Médecins Spécialistes (UEMS). 8 Modules, each accredited for 1 hour of participation.

 eCME Courses on the topic of pain