Non-Opioid Treatment

Non-opioid analgesics include various substance classes with different mechanisms of action. In addition to the classical NSAIDs and selective COX-2 inhibitors, substances such as paracetamol, flupirtine and metamizole are also members of this group.

Non-opioid analgesics can be classified due to their chemical characteristics as acid (NSAIDs = non-steroidal anti-inflammatory drugs such as ASA, ibuprofen, diclofenac, naproxen) and non-acid (paracetamol, metamizole).

The common mechanism of action of these substances is their effect on prostaglandin synthesis.


Pain Treatment

Learn more about:

  Non-pharmacological treatment



  Topical Analgesics


How do NSAIDs relieve pain?

Learn more about the mechanism of action of NSAIDs.

Mode of action


How do paracetamol and metamizole relieve pain?

Learn more about the mechanisms of action of paracetamol and metamizole

Mode of action


eCME Courses


CHANGE PAIN provides you with eCME courses – accredited by Union Européenne des Médecins Spécialistes (UEMS). 8 Modules, each accredited for 1 hour of participation.

 eCME Courses on the topic of pain