|The lidocaine plaster develops its analgesic efficacy based on two different principles:
The 5% lidocaine medicated plaster is indicated for neuropathic pain following a herpes zoster infection.
||The device as such offers an immediate cooling and soothing mechanical protection against painful as well as non-painful stimuli. By protecting e.g. against the painful rub of clothing on the skin (allodynia), the plaster may contribute significantly to improving patients quality of life.
||Topical lidocaine effects on the membranes of peripheral endings of A- and C- nerve fibres were it blocks mainly pathologically over-excitable sodium channels. This blockade inhibits sodium ion influx which is needed to generate an action potential transmitting a signal towards to central nervous system. As a consequence of the targeted blockade the neuronal membrane is stabilised, ectopic discharges are reduced and peripheral nociception is inhibited (local analgesia). As a long-term consequence, reduction of peripheral input may counteract on central sensitisation.