The lidocaine plaster develops its analgesic efficacy based on two different principles:

1.  The device as such offers an immediate cooling and soothing mechanical protection against painful as well as non-painful stimuli. By protecting e.g. against the painful rub of clothing on the skin (allodynia), the plaster may contribute significantly to improving patients quality of life.

2.  Topical lidocaine effects on the membranes of peripheral endings of A- and C- nerve fibres were it blocks mainly pathologically over-excitable sodium channels. This blockade inhibits sodium ion influx which is needed to generate an action potential transmitting a signal towards to central nervous system. As a consequence of the targeted blockade the neuronal membrane is stabilised, ectopic discharges are reduced and peripheral nociception is inhibited (local analgesia). As a long-term consequence, reduction of peripheral input may counteract on central sensitisation.

The 5% lidocaine medicated plaster is indicated for neuropathic pain following a herpes zoster infection.